Patrick Vieira’s side will take on Everton at Selhurst Park, with the tie set to be played over the weekend of March 19-20th.
The Eagles last faced Everton in this season’s Premier League, running out 3-1 winners, and were drawn from the velvet hat by Palace Academy graduate and England manager Gareth Southgate.
Everton currently sit 17th in the league, with Frank Lampard joining as manager at the end of January.
They beat Boreham Wood 2-0 to confirm their place in the quarter-final, which Palace last reached in 2018/19.
Palace booked their place in the last eight with victory over Stoke City, with Jaïro Riedewald and Cheikhou Kouyaté on the scoresheet – the south Londoners have also seen off Millwall and Hartlepool United to make it to this stage.
The FA Cup is celebrating its 150th anniversary this year, with Palace being one of the founding teams in 1871.
Full fixture details and ticketing information for the quarter-final will be released across cpfc.co.uk, the official Palace app and our social media channels shortly.